Question 1

What are the products from the reaction of excess methyl magnesium bromide with ethyl acetate followed by H3O+?

Accepted Answer

t-butanol ...

Question 2

Predict the major organic product from the following reaction.

Accepted Answer

A)   carboxylic acid
B)   ester
C)   nitrile
D)   2° amide

Question 3

Predict the major product of the following reaction.

Accepted Answer

The answer of Predict the major product of the following...

Question 4

Using 1H NMR, how would you tell the two esters apart?

Accepted Answer

In the spectrum of the first e...

Question 5

Provide the IUPAC name for HCONHCH2CH2CH3.

Accepted Answer

Question 6

A nitrile can be made by dehydrating an amide. However, for this reaction to occur, the amide must be ________.

Accepted Answer

A)   primary
B)   secondary
C)   tertiary
D)   N-methylated
E)   part of a lactam

Question 7

Predict the major organic product of the following reaction:

Accepted Answer

The answer of Predict the major organic product of the...

Question 8

Predict the major product of the following reaction.

Accepted Answer

The answer of Predict the major product of the following...

Question 9

Draw the product resulting from the following reaction. Indicate any relevant stereochemistry.

Accepted Answer

The answer of Draw the product resulting from the following...

Question 10

Provide the major organic product of the following reaction.

Accepted Answer

The answer of Provide the major organic product of the...

Question 11

Distamycin and derivatives have exhibited antiviral, antibiotic, and antitumor activity by binding to the minor groove of DNA (J. Med. Chem. 2004, 2133). Place a line through each bond of distamycin that would be cleaved by acid hydrolysis.

Accepted Answer

The answer of Distamycin and derivatives have exhibited antiviral, antibiotic,...

Question 12

List the following five compounds, ethanamide, 1-propanol, methyl formate, acetic acid, and propanenitrile, in order of increasing boiling point. Start with the lowest boiling compound.

Accepted Answer

methyl formate < pro...

Question 13

Provide a detailed, stepwise mechanism for the reaction of propanoic anhydride with phenol.

Accepted Answer

The answer of Provide a detailed, stepwise mechanism for the...

Question 14

What is the common name for the following carboxylic acid derivative?

Accepted Answer

A)   β-hydroxybutyronitrile
B)   1-cyano-2-butanol
C)   β-hydroxyvaleronitrile
D)   γ-hydroxyvaleronitrile
E)   2-hydroxypentane nitrile

Question 15

Starting from methylpropane, how could you make methyl isobutyrate?

Accepted Answer

1) Cl₂, light
2) NaOH (S_N2 condi...

Question 16

Cyclic amides are called ________.

Accepted Answer

A)   lactones
B)   lactams
C)   aminals
D)   animals
E)   imines

Question 17

Which of the following are intermediates in the acid hydrolysis of an amide?

Accepted Answer

A)   1
B)   2
C)   2 & 3
D)   4
E)   1, 2, & 3

Question 18

Arrange the carboxylic acid derivatives below in order of increasing reactivity towards nucleophilic acyl substitution.

Accepted Answer

A)   1 
B)   1 
C)   2 
D)   2 
E)   3 < 2 < 1

Question 19

Predict the major product of the following reaction.

Accepted Answer

The answer of Predict the major product of the following...

Question 20

Shown below is the structure of Lactimidomycin, a potent inhibitor of cell migration, proliferation and protein synthesis. Identify the carboxylic acid derivative/s in the structure of Lactimidomycin.

Accepted Answer

A)   Ester
B)   Anhydride
C)   Nitrile
D)   Imine

Exam 21: Carboxylic Acid Derivatives

Starting from methylpropane, how could you make methyl isobutyrate?

Correct Answerverified1) Cl2, light2) NaOH (SN2 condi...View AnswerShow Answer

Predict the major product of the following reaction.

Correct AnswerverifiedShow Answer

Provide a detailed, stepwise mechanism for the reaction of propanoic anhydride with phenol.

Correct AnswerverifiedShow Answer

What is the common name for the following carboxylic acid derivative?

Correct AnswerverifiedShow Answer

Predict the major organic product from the following reaction.

Correct AnswerverifiedShow Answer

Which of the following are intermediates in the acid hydrolysis of an amide?

Correct AnswerverifiedShow Answer

Provide the major organic product of the following reaction.

Correct AnswerverifiedShow Answer

Draw the product resulting from the following reaction. Indicate any relevant stereochemistry.

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Predict the major product of the following reaction.

Correct AnswerverifiedShow Answer

Cyclic amides are called ________.

Correct AnswerverifiedShow Answer

Shown below is the structure of Lactimidomycin, a potent inhibitor of cell migration, proliferation and protein synthesis. Identify the carboxylic acid derivative/s in the structure of Lactimidomycin.

Correct AnswerverifiedShow Answer

Distamycin and derivatives have exhibited antiviral, antibiotic, and antitumor activity by binding to the minor groove of DNA (J. Med. Chem. 2004, 2133). Place a line through each bond of distamycin that would be cleaved by acid hydrolysis.

Correct AnswerverifiedShow Answer

Arrange the carboxylic acid derivatives below in order of increasing reactivity towards nucleophilic acyl substitution.

Correct AnswerverifiedShow Answer

Using 1H NMR, how would you tell the two esters apart?

Correct AnswerverifiedIn the spectrum of the first e...View AnswerShow Answer

Provide the IUPAC name for HCONHCH2CH2CH3.

Correct AnswerverifiedShow Answer

Predict the major organic product of the following reaction:

Correct AnswerverifiedShow Answer

List the following five compounds, ethanamide, 1-propanol, methyl formate, acetic acid, and propanenitrile, in order of increasing boiling point. Start with the lowest boiling compound.

Correct Answerverifiedmethyl formate < pro...View AnswerShow Answer

What are the products from the reaction of excess methyl magnesium bromide with ethyl acetate followed by H3O+?

Correct Answerverifiedt-butanol ...View AnswerShow Answer

A nitrile can be made by dehydrating an amide. However, for this reaction to occur, the amide must be ________.

Correct AnswerverifiedShow Answer

Predict the major product of the following reaction.

Correct AnswerverifiedShow Answer

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1) Cl₂, light
2) NaOH (S_N2 condi...
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Using ¹H NMR, how would you tell the two esters apart?

Correct Answer
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In the spectrum of the first e...
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Provide the IUPAC name for HCONHCH₂CH₂CH₃.

Correct Answer
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methyl formate < pro...
View Answer

What are the products from the reaction of excess methyl magnesium bromide with ethyl acetate followed by H₃O⁺?

Correct Answer
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t-butanol ...
View Answer

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Correct Answer
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