Question 1

You are working to identify enhancer regions of a particular gene.The best place to look is

Accepted Answer

A)  immediately upstream of the promoter.
B)  immediately downstream of the promoter.
C)  primarily upstream of the promoter,possibly some distance away.
D)  primarily downstream of the promoter,including the exons of the coding region.

Question 2

The most common DNA-binding motif is the

Accepted Answer

A)  nonhelical zipper.
B)  leucine zipper.
C)  zinc finger.
D)  homeodomain.
E)  helix-turn-helix. E

Question 3

The progesterone receptor (PR) is a steroid hormone receptor and transcription factor.The protein SRC-1,which does not bind DNA by itself,can bind to PR and increase expression of genes regulated by PR.Based on this information,SRC-1 is best described as a(n)

Accepted Answer

A)  coactivator.
B)  inducer.
C)  general transcription factor.
D)  specific transcription factor.

Question 4

Regulatory proteins can identify specific sequences on the DNA double helix without unwinding the helix.This is accomplished by inserting

Accepted Answer

A)  RNA promoters into either the major groove or the minor groove of the double helix where the edges of the nitrogen bases protrude.
B)  DNA-binding motifs into the minor groove of the double helix where the edges of the nitrogen bases protrude.
C)  DNA polymerase into the major groove of the double helix where the edges of the nitrogen bases protrude.
D)  RNA polymerase into the major groove of the double helix where the edges of the nitrogen bases protrude.
E)  DNA-binding motifs into the major groove of the double helix where the edges of the nitrogen bases protrude.

Question 5

Examples of shapes in regulatory proteins that are used to bind to DNA include (check all that apply)

Accepted Answer

A)  zinc finger.
B)  TATA box.
C)  helix-turn-helix.
D)  leucine zipper.
E)  Doubledomain.

Question 6

A protein that regulates transcription by binding to the operator is known as the

Accepted Answer

A)  operon.
B)  repressor.
C)  promoter.
D)  operator.
E)  CAP.

Question 7

The enzyme dicer chops dsRNA molecules into small pieces of

Accepted Answer

A)  mRNA and miRNA.
B)  miRNA and siRNA.
C)  siRNA and rRNA.
D)  mRNA and siRNA. B

Question 8

You are studying the effects of specific transcription factors on the activation of gene expression.You notice that one particular transcription factor binds far away from the promoter of its target gene.What can explain this?

Accepted Answer

A)  The transcription factor transcribes small RNAs that then bind to the promoter and activate the gene's expression.
B)  The transcription factor tags the enhancer with ubiquitin to stimulate transcription.
C)  DNA looping brings the transcription factor closer to the promoter and initiates gene transcription.
D)  RNA looping brings the transcription factor closer to the promoter and initiates gene transcription. C

Question 9

In multicellular organisms,the mechanism most directly responsible for directing development and maintaining homeostasis is gene

Accepted Answer

A)  mutation.
B)  duplication.
C)  deletion.
D)  regulation.

Question 10

In your research,you have discovered that Protein X is often ubiquitinated in people with a certain disease.What would you predict about levels of Protein X in these patients?

Accepted Answer

A)  Levels of Protein X will be low due to degradation in the proteasome.
B)  Levels of Protein X will be the same,just carrying a ubiquitin tag.
C)  Levels of Protein X will be increased due to transcriptional activation.
D)  Levels of Protein X will be decreased due to negative feedback on transcription.
E)  Levels of Protein X will be increased due to protection from degradation.

Question 11

When E.coli cells produce the amino acid tryptophan,a cluster of five genes is transcribed together.This cluster of genes is referred to as the

Accepted Answer

A)  trp transcriptional operator.
B)  trp regulator.
C)  trp suppressor.
D)  trp operon.
E)  trp promoter.

Question 12

Vertebrate cells possess a protein that binds to clusters of 5-methylcytosine and ensures the gene will stay in the "off" position.This control of gene regulation is a result of

Accepted Answer

A)  translation.
B)  enhancer expression.
C)  methylation.
D)  promoter expression.
E)  operator suppression.

Question 13

In some organisms,the primary function of a gene in a cell is to participate in regulating the body as a whole rather than responding to the cell's immediate environment.These organisms would be

Accepted Answer

A)  multicellular.
B)  diploid.
C)  bacterial.
D)  prokaryotic.

Question 14

The enzyme beta-galactosidase acts on lactose to form galactose.In turn,the presence of galactose leads to expression of the enzymes responsible for the metabolism of galactose.In this case,lactose is serving as a carbon source and as a(n)

Accepted Answer

A)  inducer.
B)  repressor.
C)  DNA-binding protein.
D)  operon.

Question 15

The p300/CBP (CREB-binding protein) proteins are histone acetyltransferases that help regulate the transcription of many genes.Based on this information you can conclude that these proteins

Accepted Answer

A)  acetylate purines.
B)  remodel chromatin.
C)  recruit helicases.
D)  physically connect activator proteins.

Question 16

The basic tool of genetic regulation is the ability of certain proteins to bind to specific

Accepted Answer

A)  regulatory RNA sequences.
B)  regulatory DNA sequences.
C)  repressor parts of the gene.
D)  promoter parts of the gene.
E)  enzymes of the cell.

Question 17

The primary transcripts in eukaryotes are most accurately described as

Accepted Answer

A)  composed of RNA polymerase and associated histones.
B)  having the exons removed and the introns retained for translation.
C)  a faithful copy of the entire gene including exons and introns.
D)  an exact copy of the gene,but the introns have been removed.
E)  an RNA copy,but the noncoding exons and introns have been removed.

Question 18

As a microbiologist you have been asked to investigate the regulation of a novel gene in a bacterial species.Given what is known about bacteria,the logical place to begin your investigation is

Accepted Answer

A)  transcriptional regulation.
B)  translational regulation.
C)  alternative splicing regulation.
D)  regulation by enhancer elements.
E)  regulation by general transcription factors.

Question 19

The TFIID complex is formed by

Accepted Answer

A)  TATA-binding protein TBP and TAFs.
B)  TATA-binding protein TBP,TAFs and RNA pol II.
C)  TAFs and the core promoter.
D)  TATA-binding protein and activators.

Question 20

What is the difference between a gene that is derepressed and one that is induced?

Accepted Answer

A)  A gene that is derepressed is turned on because a repressor protein is not bound without its cofactor.By comparison,a gene that is induced is turned on because an inducer molecule prevents binding of the repressor.
B)  Genes that are derepressed are turned on because an inducer molecule is present.By comparison,a gene that is induced is turned on because a repressor protein is bound to the operator.
C)  There is no difference between a gene that is derepressed and one that is induced.
D)  A derepressed gene is turned off and an induced gene is activated to be expressed.

Exam 16: Control of Gene Expression

You are working to identify enhancer regions of a particular gene.The best place to look is

Correct AnswerverifiedShow Answer

The most common DNA-binding motif is the

Correct AnswerverifiedE

The progesterone receptor (PR) is a steroid hormone receptor and transcription factor.The protein SRC-1,which does not bind DNA by itself,can bind to PR and increase expression of genes regulated by PR.Based on this information,SRC-1 is best described as a(n)

Correct AnswerverifiedShow Answer

Regulatory proteins can identify specific sequences on the DNA double helix without unwinding the helix.This is accomplished by inserting

Correct AnswerverifiedShow Answer

Examples of shapes in regulatory proteins that are used to bind to DNA include (check all that apply)

Correct AnswerverifiedShow Answer

A protein that regulates transcription by binding to the operator is known as the

Correct AnswerverifiedShow Answer

The enzyme dicer chops dsRNA molecules into small pieces of

Correct AnswerverifiedB

You are studying the effects of specific transcription factors on the activation of gene expression.You notice that one particular transcription factor binds far away from the promoter of its target gene.What can explain this?

Correct AnswerverifiedC

In multicellular organisms,the mechanism most directly responsible for directing development and maintaining homeostasis is gene

Correct AnswerverifiedShow Answer

In your research,you have discovered that Protein X is often ubiquitinated in people with a certain disease.What would you predict about levels of Protein X in these patients?

Correct AnswerverifiedShow Answer

When E.coli cells produce the amino acid tryptophan,a cluster of five genes is transcribed together.This cluster of genes is referred to as the

Correct AnswerverifiedShow Answer

Vertebrate cells possess a protein that binds to clusters of 5-methylcytosine and ensures the gene will stay in the "off" position.This control of gene regulation is a result of

Correct AnswerverifiedShow Answer

In some organisms,the primary function of a gene in a cell is to participate in regulating the body as a whole rather than responding to the cell's immediate environment.These organisms would be

Correct AnswerverifiedShow Answer

The enzyme beta-galactosidase acts on lactose to form galactose.In turn,the presence of galactose leads to expression of the enzymes responsible for the metabolism of galactose.In this case,lactose is serving as a carbon source and as a(n)

Correct AnswerverifiedShow Answer

The p300/CBP (CREB-binding protein) proteins are histone acetyltransferases that help regulate the transcription of many genes.Based on this information you can conclude that these proteins

Correct AnswerverifiedShow Answer

The basic tool of genetic regulation is the ability of certain proteins to bind to specific

Correct AnswerverifiedShow Answer

The primary transcripts in eukaryotes are most accurately described as

Correct AnswerverifiedShow Answer

As a microbiologist you have been asked to investigate the regulation of a novel gene in a bacterial species.Given what is known about bacteria,the logical place to begin your investigation is

Correct AnswerverifiedShow Answer

The TFIID complex is formed by

Correct AnswerverifiedShow Answer

What is the difference between a gene that is derepressed and one that is induced?

Correct AnswerverifiedShow Answer

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