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Exam 12: The Cell Cycle

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Question 1

Multiple Choice

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Which of the following is True concerning cancer cells?

A) They do not exhibit density-dependent inhibition when growing in culture.
B) When they stop dividing, they do so at random points in the cell cycle.
C) They are not subject to cell cycle controls.
D) B and C only
E) A, B, and C

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Question 2

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If mammalian cells receive a go-ahead signal at the G₁ checkpoint, they will

A) move directly into telophase.
B) complete the cycle and divide.
C) exit the cycle and switch to a nondividing state.
D) show a drop in MPF concentration.
E) complete cytokinesis and form new cell walls.

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B

Question 3

Multiple Choice

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Vinblastine is a standard chemotherapeutic drug used to treat cancer. Because it interferes with the assembly of microtubules, its effectiveness must be related to

The following questions are based on Figure 12.3. -Which number represents the point in the cell cycle during which the chromosomes are replicated?

Use the following information to answer the questions below. The lettered circle in Figure 12.1 shows a diploid nucleus with four chromosomes. There are two pairs of homologous chromosomes, one long and the other short. One haploid set is symbolized as black and the other haploid set is gray. The chromosomes in the unlettered circle have not yet replicated. Choose the correct chromosomal conditions for the following stages. -Which term describes centromeres uncoupling, sister chromatids separating, and the two new chromosomes moving to opposite poles of the cell?

A mutation results in a cell that no longer produces a normal protein kinase for the M phase checkpoint. Which of the following would likely be the immediate result of this mutation?

A group of cells is assayed for DNA content immediately following mitosis and is found to have an average of 8 picograms of DNA per nucleus. Those cells would have __________ picograms at the end of the S phase and __________ picograms at the end of G₂.

In order for anaphase to begin, which of the following must occur?

The drug cytochalasin B blocks the function of actin. Which of the following aspects of the cell cycle would be most disrupted by cytochalasin B?

An enzyme that attaches a phosphate group to another molecule is called a

Figure 12.2 -If there are 20 centromeres in a cell at anaphase, how many chromosomes are there in each daughter cell following cytokinesis?

DNA is replicated at this time of the cell cycle:

Fibroblasts have receptors for this substance on their plasma membranes:

Movement of the chromosomes during anaphase would be most affected by a drug that

The centromere is a region in which

Which of the following is a protein maintained at constant levels throughout the cell cycle that requires cyclin to become catalytically active?

Use the data in Table 12.1 to answer the following questions. The data were obtained from a study of the length of time spent in each phase of the cell cycle by cells of three eukaryotic organisms designated beta, delta, and gamma. $\begin{array} { l r r r r } \text { Cell Type } & \mathrm { G } _ { 1 } & \mathrm {~S} & \mathrm { G } _ { 2 } & M \\\hline \text { Beta } & 18 & 24 & 12 & 16 \\\text { Delta } & 100 & 0 & 0 & 0 \\\text { Gamma } & 18 & 48 & 14 & 20\end{array}$ Table 12.1: Minutes Spent in Cell Cycle Phases -Of the following, the best conclusion concerning the difference between the S phases for beta and gamma is that

Besides the ability of some cancer cells to overproliferate, what else could logically result in a tumor?

The decline of MPF activity at the end of mitosis is due to

Where do the microtubules of the spindle originate during mitosis in both plant and animal cells?