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The megakaryocyte is a precursor to


A) factor IX.
B) white blood cells.
C) red blood cells.
D) platelets.

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A 3-year-old boy who exhibits prolonged bleeding after minor trauma and a prolonged aPTT,but a normal platelet count,is likely to be diagnosed with


A) hemophilia.
B) liver dysfunction.
C) disseminated intravascular coagulation.
D) thrombocytopenia.

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Treatment for hemophilia A includes


A) heparin administration.
B) factor IX replacement.
C) factor VIII replacement.
D) platelet transfusion.

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Dysfunction of which organ would lead to clotting factor deficiency?


A) Liver
B) Kidney
C) Spleen
D) Pancreas

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A male patient involved in a motor vehicle accident is brought to the emergency department with acute flank pain.What additional signs of bleeding may the patient exhibit? (Select all that apply.)


A) Hematuria
B) Melena
C) Hematemesis
D) Menorrhagia
E) Hemoptysis

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Activation of the extrinsic pathway of coagulation is initiated by


A) platelet factors.
B) collagen exposure.
C) tissue thromboplastin.
D) factor VII.

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The final step in clot formation is


A) conversion of prothrombin to thrombin.
B) platelet degranulation and adhesion.
C) conversion of fibrinogen to fibrin.
D) clot retraction.

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A patient is diagnosed with a tortuous blood vessel of the right hand that bleeds spontaneously.This patient presents with


A) petechiae.
B) purpura.
C) telangiectasia.
D) thrombocytosis.

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C

The activated partial thromboplastin time (aPTT) is a measure of the integrity of


A) the extrinsic pathway.
B) the intrinsic pathway.
C) factor VIII synthesis.
D) plasminogen.

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A patient presents to the physician's office with pinpoint hemorrhages on the skin.The patient is most likely between the ages of _____ years.


A) 6 months and 2
B) 4 and 7
C) 15 and 18
D) 25 and 45

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B

A commonly ingested substance associated with prolongation of the bleeding time is


A) acetaminophen.
B) tobacco.
C) caffeine.
D) aspirin.

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D

A newborn has melena,bleeding from the umbilicus,and hematuria.The newborn most likely experiencing


A) vitamin K deficiency bleeding.
B) acquired vitamin K deficiency.
C) von Willebrand disease.
D) disseminated intravascular coagulation.

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Disseminated intravascular coagulation may be treated with heparin therapy to


A) enhance fibrinolysis.
B) inhibit clotting factor consumption.
C) activate platelets.
D) enhance liver synthesis of clotting factors.

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A normal bleeding time in association with normal platelet count,and increased prothrombin time (PT) and INR,is indicative of


A) vitamin K deficiency.
B) hemophilia B.
C) hemophilia A.
D) idiopathic thrombocytopenia.

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Widespread activation of the clotting cascade secondary to massive trauma is called


A) hemophilia B.
B) disseminated intravascular coagulation (DIC) .
C) Hageman disease.
D) idiopathic thrombocytopenia purpura.

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Hemophilia B is also known as Christmas disease.

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The liver is responsible for the synthesis of coagulation factors,with the exception of part of VIII.

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The prothrombin time (PT) and INR (international normalized ratio) measure the integrity of


A) platelet function.
B) extrinsic pathway.
C) intrinsic pathway.
D) fibrinolysis.

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A cause of thrombocytopenia includes


A) hypoxemia.
B) reduced erythropoietin.
C) chemotherapy.
D) secondary polycythemia.

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Which diseases may be associated with a bleeding problem? (Select all that apply.)


A) Urinary retention
B) Renal failure
C) Cirrhosis
D) Systemic lupus erythematosus
E) Ovarian cancer

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