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Which of the following is not true of influenza?


A) Influenza has glycoprotein spikes of hemagglutinin (H) and neuraminidase (N) .
B) Antigenic drift changes the antigens to reduce immune recognition.
C) Antigenic shift causes changes in the RNA strands.
D) Influenza B viruses undergo both antigenic drift and antigenic shift.
E) H5N1 is the bird flu strain that may cause a pandemic.

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Influenza viruses A and B contain eight RNA strands and influenza virus C has seven strands.During antigenic drift,genes coding for glycoproteins recognized by the host immune system are mutated,whereas during antigenic shift,whole RNA strands can be swapped with those of another influenza virus,greatly increasing the virulence and transmissibility of the virus and minimizing the ability of the host's defenses to recognize it.Which of the following statements is true?


A) Genetic drift creates a need for an annual flu vaccine to keep up with the seasonal genetic changes,and if Genetic shift occurs,an additional vaccine will have to be administered since the shift creates a different strainof virus.
B) Genetic drift creates a need for an annual flu vaccine to keep up with the seasonal genetic changes,and if a Genetic shift occurs,the same vaccine will be effective against both strains.
C) If a novel strain resulting from antigenic shift appears, it is not necessary to get vaccinated because these strains are typically less pathogenic than seasonal strains.
D) The worst influenza pandemics throughout history have occurred as a result of genetic drift rather than genetic shift.

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Antibiotic treatment immediately upon the diagnosis of otitis media is standard procedure today.

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The highest incidence of histoplasmosis in the United States occurs in the ______.


A) southeast
B) southwest
C) east and Midwest
D) northeast
E) Rocky Mountains

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The pathogen that causes Legionnaires'pneumonia also causes a milder infection called Pontiac fever.

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Which of the following statements is false regarding RSV?


A) While RSV is most prevalent in infants 6 months of age and younger, the highest mortality rate is in those children with underlying risk factors such as prematurity.
B) Infants aged 6 months and younger are the most susceptible to infection by RSV; however, adults and older children can also become infected with this virus.
C) RSV infects infants aged 6 months and younger; it is unlikely that a 4-year-old would develop a respiratory disease as a result of this virus.
D) Although RSV is most prevalent in infants aged 6 months and younger, usually by age 2 most children have been exposed to this virus.

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Which of the following is/are the main causative agent/s of pharyngitis?


A) Streptococcus pyogenes
B) Aspergillus fumigatus
C) Viruses
D) Both Aspergillus fumigatus and viruses are correct.
E) Both Streptococcus pyogenes and viruses are correct.

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Inhalation of respiratory secretions is involved in the transmission of all of the following except ______.


A) influenza
B) rhinitis
C) legionella
D) diphtheria
E) SARS

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Influenza virus can exhibit constant mutation of viral glycoproteins,called antigenic ________,or alternatively antigenic ________,which is a more serious phenomenon caused by the exchange of a viral gene with that of another influenza virus strain.


A) drift; exchange
B) exchange; drift
C) drift; shift
D) shift; drift

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What features of the respiratory system protect it from infection?


A) Nasal hairs
B) Cilia
C) Mucus
D) Macrophages
E) All of the choices are correct.

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Otitis media is commonly treated with broad spectrum antibiotics,although there is a lot of push-back or pressure against doing this.Why are these drugs given for this condition?


A) No other kinds of drugs and antibiotics can kill the bacteria causing otitis media other than the broad- spectrum class of drugs.
B) The narrow-spectrum drugs are very toxic as opposed to the rather benign broad-spectrum ones.
C) Otitis media is often caused by a variety of bacteria growing together in a biofilm, and the bacteria often exhibit different susceptibilities to drugs.
D) Fungi are the most common cause of otitis media, and the fungi do not respond well to the narrow-spectrum drugs.

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Pneumonias have different signs and symptoms depending on whether they are classified as CAP or HCAP.

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Infection travels to the middle ear by way of the ______.


A) auditory canal
B) sinuses
C) nasal cavity
D) eustachian (auditory) tubes
E) subarachnoid space

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Pertussis has been making a big comeback in the last few years,after being on the decline for quite a long time.Why is this?


A) Few people have ever received pertussis vaccines because there have been links to autism.
B) The strain of Bordetella pertussis that is now the major cause of pertussis is much more virulent than earlier strains.
C) The pertussis vaccine does not seem to protect for a lifetime, so those who received the vaccine as kids may become susceptible in adulthood.
D) People eat so much refined sugars and starches that our immune systems are much weaker, thereby not being able to adequately protect against pertussis bacteria.

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Which is not correct about Mycobacterium species?


A) All species are human pathogens.
B) Cell walls have waxy lipids.
C) It is an acid-fast bacterium.
D) It exhibits a very slow growth rate.
E) Cells appear as long, slender rods via microscopy.

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Rheumatic fever is caused by a(n) _____ infection.


A) primary streptococcal
B) primary viral
C) opportunistic streptococcal
D) endogenous

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Both Streptococcus pyogenes and Corynebacterium diphtheriae are highly pathogenic,and the disease symptomology can be very severe.Why is this?


A) Infants and children are the high-risk groups, and their mortality rate is higher than for other ages.
B) Both bacteria produce potent exotoxins.
C) They induce autoimmune states in the patients.
D) There are no antibiotics useful for diseases caused by these bacteria.

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The most common type of virus leading to rhinitis is _______.


A) coronavirus
B) adenovirus
C) rhinovirus
D) herpes simplex virus
E) retrovirus

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The most common causative agent of otitis media is ______.


A) Aspergillus fumigatus
B) Haemophilus influenzae
C) Candida albicans
D) Corynebacterium diphtheriae
E) Streptococcus pneumoniae

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Mycobacterium tuberculosis


A) produces several virulence factor enzymes and an exotoxin.
B) integrates its genome into host cell DNA.
C) can survive for 8 months in fine aerosol particles.
D) has a capsule.
E) lives in the soil.

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