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Endocarditis is often a consequence of bacteria attached to the heart valves.These microbes are not eliminated by circulating lymphocytes because


A) lymphocytes cannot engulf microbes attached to tissue.
B) Gram-positive microbes don't have an exotoxin surface molecule to trigger an immune response.
C) these microbes become covered in platelets and fibrin which is not recognized as foreign by the immune system.
D) lymphocytes do not circulate through the heart valves to detect the presence of microbes.

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In severe cases of Rocky Mountain spotted fever,the enlarged lesions of the rash can become necrotic and predispose the patient to gangrene of toes and fingertips.

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Lyme disease is transmitted by ______.


A) droplets
B) ticks
C) lice
D) fleas
E) flies

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Humans should be routinely vaccinated against Lyme disease.

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The causative organism of malaria is a ______.


A) prion
B) fungus
C) virus
D) protozoan
E) bacterium

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Which of the following statements regarding HIV is incorrect?


A) The virus attaches to host cells with CD4 receptors.
B) PCR is the primary technique for detecting HIV in blood.
C) The viral DNA integrates into the host DNA.
D) The virus becomes latent in host cells.
E) The virus can enter into nervous tissues and cause abnormalities.

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Lyme disease is only seen in people living in Lyme,Connecticut.

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The most important defense of the cardiovascular system against infection is ______.


A) lymphocytes in the blood
B) lymph nodes
C) the blood-brain barrier
D) fever

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Malaria may be prevented by


A) using bed nets sprayed with insecticide.
B) eliminating standing water.
C) taking prophylactic drugs.
D) using genetically engineered mosquitoes.
E) All of the choices are correct.

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Which of the following is not true of Ebola and Marburg?


A) Blood clotting is disrupted in an infection with these viruses.
B) They are filoviruses.
C) There is currently no effective treatment for infected individuals.
D) They transmitted by direct contact with body fluids from affected individuals.
E) The viruses are transmitted by mosquitoes.

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Rifampin is the drug of choice for malaria.

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Which of the following is not true of tularemia?


A) Its symptoms include fever, swollen lymph nodes, ulcerative lesions, conjunctivitis, and pneumonia.
B) It is a zoonosis.
C) It is sometimes called rabbit fever.
D) The causative agent is a gram-positive bacterium.
E) It is transmitted by arthropod vectors.

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Plague exhibits a


A) septic form historically called the Black Death.
B) bubonic form in which swollen lesions termed buboes develop.
C) pneumonic form that manifests as a respiratory disease.
D) All of the choices are correct.

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Which of the following statements regarding the structure of blood vessels is incorrect?


A) In contrast to veins, arteries have higher blood pressure, more tissue layers, and are thinner vessels.
B) Connective tissue and muscle fibers are found in the layers of tissue surrounding both arteries and veins.
C) Capillaries have only a single layer of endothelium, rendering them fragile and leaky during an infection with a hemorrhagic fever virus.
D) Blood vessels are often found in parallel with lymphatic vessels.

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Which of the following statements regarding the Epstein-Barr virus is incorrect?


A) The virus has a 30-50 day incubation period.
B) The virus is transmitted by direct oral contact and saliva.
C) An infection typically requires hospitalization for about a week.
D) An infection results in sudden leukocytosis.
E) Transmission has been documented through contaminated blood transfusions and organ transplants.

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Which of the following statements regarding the development of AIDS following infection with HIV is incorrect?


A) Antibodies to HIV antigens formed in response to HIV infection appear within a few weeks of infection and remain high through latency and AIDS.
B) CD4 T cells are present in low numbers in an uninfected individual, but become elevated upon HIV infection, and ultimately fall to very low numbers (<200 cells/ml) as the infection progresses to AIDS.
C) Viral antigens can be detected at high levels in the blood within days following infection, then their numbers fall dramatically during a latent period and rise again when AIDS symptoms occur.
D) An HIV-positive individual in the latency phase can be distinguished from an uninfected individual by the presence of antibodies to HIV antigens in their blood.

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Despite the aggressive defense of the cardiovascular system by the immune system,some microbes can invade and establish an infection in the blood.From the following list of microbes and their virulence factors,identify the mismatch.


A) Bacillus anthracis produces antioxidants to combat lysosomes.
B) Coxiella burnetii produces an endospore-like structure.
C) Trypanosoma cruzi cloaks itself in host proteins to avoid immune recognition.
D) Borrelia burgdorferi changes its surface antigens to avoid immune recognition.

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Anthrax is not routinely diagnosed in the U.S.because


A) it is a rare infection.
B) infections are usually asymptomatic.
C) infection is generally only seen in late-stage AIDS patients.
D) health care workers haven't been trained to detect it.

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The causative agent in a case of sepsis can be isolated by


A) inoculating blood agar with a sample of the patient's blood.
B) performing a Kirby-Bauer assay on a sample of the patient's blood.
C) sending a blood sample to the CDC laboratories in Atlanta.
D) centrifugation of the blood to separate cells and plasma.

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Anthrax is


A) a zoonosis.
B) transmitted by contact, inhalation, or ingestion.
C) a disease that, in humans, can cause a rapidly fatal toxemia and septicemia.
D) only seen sporadically in the United States.
E) All of the choices are correct.

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