Question 1

The 10,000 origins of replication in mammalian cells suggests that concerning origin of replication there is

Accepted Answer

A)  at least one per loop of DNA.
B)  probably one every other loop of DNA
C)  a random distribution across the genome.
D)  a precise pattern of distribution relative to other replication points A

Question 2

Which of the following is a predicted consequence of kinetochores not achieving the correct level of tension from the mitotic spindle?

Accepted Answer

A)  The chromosomes will dissociate from their centromeres
B)  All chromosomes will migrate to one pole instead of to two opposite poles
C)  Mitosis will not progress beyond metaphase
D)  No prediction can be made

Question 3

One of the functions of a centromere is to contribute to proper chromosome segregation.The other function is to

Accepted Answer

A)  hold sister chromatids together.
B)  ensure that proper chromosome arm length is maintained.
C)  allow easy karyotyping.
D)  develop meiotic chromosome replication. A

Question 4

In DNA, the 300Å fiber is formed into structural loops.Responsibility for this function appears to lie with

Accepted Answer

A)  histone H4.
B)  nucleosomase.
C)  histone H1.
D)  certain nonhistone proteins.

Question 5

What is true about new nucleosome formation during DNA replciation?

Accepted Answer

A)  Nucleosomes will be composed of different combinations of H3/H4 tetramers and H2A/H2B that are either newly synthesized or were from previous histone octamers.
B)  Nucleosomes will be composed of different combinations of H3/H2A tetramers and H4/H2B that are either newly synthesized or were from previous histone octamers.
C)  One DNA strand will have newly synhtesized octamers and the other will have previously synthesized octamers.
D)  Nucleosomes will be composed of different combinations of H2A/H2BH3/H4 tetramers that are either newly synthesized or were from previous histone octamers.

Question 6

In the position effect variegation of red and white eye color in Drosophila, eyes are produced

Accepted Answer

A)  one red and one white.
B)  red or white depending on which gene is dominant.
C)  with every other eye facet red or white.
D)  with varying sizes and positions of red and white patches.

Question 7

Which of the following predictions could you make about a cell in which the HP1 protein were disabled?

Accepted Answer

A)  Methylation of DNA would increase.
B)  The entirely of the cell's chromosomes would be condensed into heterochromatin.
C)  Histone methyltransferase would bind to chromatin more easily.
D)  Heterochromatin would not be formed.

Question 8

You are studying a histone complex that contains an unusually high level of modification with acetyl groups.What can you conclude about the DNA bound to this histone complex?

Accepted Answer

A)  It contains actively transcribed genes.
B)  It is most likely heterochromatin.
C)  It is most likely telomeric.
D)  It is most likely derived from a condensed Barr body.

Question 9

A yeast artificial chromosome (YAC)  usually consists of

Accepted Answer

A)  a yeast centromere.
B)  a yeast origin of replication.
C)  telomere sequences.
D)  suitable selectable markers.
E)  All of the choices are correct.

Question 10

The single-celled yeast, Saccharomyces cerevisiae, was the organism of choice as raw material for constructing artificial chromosomes because of all the following except that

Accepted Answer

A)  it is easy to manipulate.
B)  it is unicellular.
C)  its genetic machinery is similar to the one in higher organisms.
D)  its origins of replication have been defined as discrete, small segments of DNA.

Question 11

The two chromatids of each replicated chromosome must separate from one another and segregate during

Accepted Answer

A)  mitosis.
B)  meiosis I.
C)  meiosis II.
D)  both mitosis and meiosis I.
E)  both mitosis and meiosis II.

Question 12

When constructing a YAC, why must a large amount of random DNA be included?

Accepted Answer

A)  The random DNA base pairs with DNA in the natural chromosomes of a cell.
B)  YACs that are too small do not segregate properly during mitosis and the random DNA is used as filler.
C)  The random DNA functions as telomeres.
D)  The random DNA contains origins of replication needed for maintenance of the YAC.
E)  The random DNA allows YACs to be used in both eukaryotic and prokaryotic cells.

Question 13

Histones and DNA have a strong attraction for each other because

Accepted Answer

A)  DNA is positively charged and histones are negatively charged.
B)  both DNA and proteins are hydrophobic.
C)  DNA is negatively charged and histones are positively charged.
D)  like substances share common charges.

Question 14

The total compaction of DNA as seen in metaphase chromosomes is approximately ______ fold.

Accepted Answer

A)  10,000
B)  50,000
C)  100,000
D)  40

Question 15

In yeast chromosomes, centromeres

Accepted Answer

A)  help distinguish one chromosome from another.
B)  are closely related in sequence.
C)  are only 10-15 bp long.
D)  play various roles in chromosome segregation.

Question 16

During mitosis, kinetochores develop during

Accepted Answer

A)  telophase.
B)  anaphase.
C)  metaphase.
D)  prophase.

Question 17

By weight, chromatin consists roughly of

Accepted Answer

A)  1/3 DNA, 1/3 histones, and 1/3 nonhistones.
B)  1/3 DNA and 2/3 acidic proteins.
C)  1/3 DNA, 1/3 histones, and 1/3 basic proteins.
D)  1/4 DNA, 1/4 RNA, 1/4 histones, and 1/4 nonhistones.

Question 18

In DNA, most satellite sequences are found in

Accepted Answer

A)  chromosome arms.
B)  telomeres.
C)  centromeres.
D)  spaces around the dark bands. C

Question 19

The components of a chromosome include one long DNA molecule and

Accepted Answer

A)  phospholipids.
B)  proteins.
C)  carbohydrates.
D)  steroids.
E)  RNA.

Question 20

Which of the following is not usually seen when a cell loses telomerase activity?

Accepted Answer

A)  Telomeres shorten slightly with each cell division.
B)  After 30-50 divisions, cells show signs of senescence and then die.
C)  In the immune system, certain capacity for protection is gradually lost.
D)  Many normal somatic cells gain the ability to divide indefinitely.

Exam 11: The Eukaryotic Chromosome

The 10,000 origins of replication in mammalian cells suggests that concerning origin of replication there is

Correct AnswerverifiedA

Which of the following is a predicted consequence of kinetochores not achieving the correct level of tension from the mitotic spindle?

Correct AnswerverifiedShow Answer

One of the functions of a centromere is to contribute to proper chromosome segregation.The other function is to

Correct AnswerverifiedA

In DNA, the 300Å fiber is formed into structural loops.Responsibility for this function appears to lie with

Correct AnswerverifiedShow Answer

What is true about new nucleosome formation during DNA replciation?

Correct AnswerverifiedShow Answer

In the position effect variegation of red and white eye color in Drosophila, eyes are produced

Correct AnswerverifiedShow Answer

Which of the following predictions could you make about a cell in which the HP1 protein were disabled?

Correct AnswerverifiedShow Answer

You are studying a histone complex that contains an unusually high level of modification with acetyl groups.What can you conclude about the DNA bound to this histone complex?

Correct AnswerverifiedShow Answer

A yeast artificial chromosome (YAC) usually consists of

Correct AnswerverifiedShow Answer

The single-celled yeast, Saccharomyces cerevisiae, was the organism of choice as raw material for constructing artificial chromosomes because of all the following except that

Correct AnswerverifiedShow Answer

The two chromatids of each replicated chromosome must separate from one another and segregate during

Correct AnswerverifiedShow Answer

When constructing a YAC, why must a large amount of random DNA be included?

Correct AnswerverifiedShow Answer

Histones and DNA have a strong attraction for each other because

Correct AnswerverifiedShow Answer

The total compaction of DNA as seen in metaphase chromosomes is approximately ______ fold.

Correct AnswerverifiedShow Answer

In yeast chromosomes, centromeres

Correct AnswerverifiedShow Answer

During mitosis, kinetochores develop during

Correct AnswerverifiedShow Answer

By weight, chromatin consists roughly of

Correct AnswerverifiedShow Answer

In DNA, most satellite sequences are found in

Correct AnswerverifiedC

The components of a chromosome include one long DNA molecule and

Correct AnswerverifiedShow Answer

Which of the following is not usually seen when a cell loses telomerase activity?

Correct AnswerverifiedShow Answer

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C

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