Question 1

An example of the utility of gene expression profiling in a clinical situation is

Accepted Answer

A)  finding that a child has inherited a certain genotype.
B)  identifying genes with aberrant expression levels in cancers likely to spread.
C)  determining whether a medical condition is inherited or not.
D)  replacing a gene bearing a mutation with a wild type version in the affected tissue.

Question 2

Histone proteins

Accepted Answer

A)  are male sex hormones.
B)  are inert spool-like structural supports around which DNA winds.
C)  control gene expression through chemical interactions that expose parts of the DNA to transcription factors,while shielding other parts.
D)  bind to mRNAs,preventing their translation into protein. C

Question 3

About _____ percent of the human genome actually encodes proteins.

Accepted Answer

A)  0.5
B)  1.5
C)  5.0
D)  10
E)  100

Question 4

The promoter of a gene is the part of a gene where RNA polymerase and transcription factors bind,marking the _____.

Accepted Answer

A)  end point of transcription
B)  start point of transcription
C)  end point of translation
D)  start point of translation

Question 5

Modifiers of gene expression include

Accepted Answer

A)  isolated amino acids and tRNAs.
B)  specific classes of proteins and RNA molecules.
C)  specific classes of lipids and carbohydrates.
D)  nicotine and alcohol.

Question 6

Understanding the signals that activate pancreatic stem cells to differentiate as beta cells could be used to treat

Accepted Answer

A)  restless legs syndrome.
B)  male infertility.
C)  endometriosis.
D)  diabetes mellitus.

Question 7

The most important chemical group that determines how tightly histones bind DNA is

Accepted Answer

A)  acetyl.
B)  methyl.
C)  ethyl.
D)  phosphate.

Question 8

About _____ percent of human genes are alternately spliced.

Accepted Answer

A)  10
B)  40
C)  75
D)  90

Question 9

The complexity of microRNA function is that

Accepted Answer

A)  microRNAs can be rRNA,mRNA,or tRNA.
B)  they range in size from 10 to 10,000 bases.
C)  a microRNA type can bind several mRNAs,and an mRNA can bind several microRNAs.
D)  it can be acetylated,phosphorylated,or methylateD.

Question 10

MicroRNAs bind to

Accepted Answer

A)  the 3' ends of specific mRNAs.
B)  the 5' ends of specific rRNAs.
C)  the 3' ends of specific tRNAs.
D)  the 4' ends of specific mRNAs. A

Question 11

Fetal hemoglobin is hemoglobin that consists of two gamma chains and _____.

Accepted Answer

A)  two alpha chains
B)  two beta chains
C)  two zeta chains
D)  two epsilon chains

Question 12

Fetal hemoglobin carries _____ percent more oxygen than adult hemoglobin.

Accepted Answer

A)  5 to 10
B)  20 to 30
C)  50 to 60
D)  80 to 90

Question 13

In the adult pancreas,the beta,alpha,gamma,and F cells are

Accepted Answer

A)  stem cells.
B)  progenitor cells.
C)  differentiated cells.
D)  blood cells.

Question 14

A mutation in a promoter causes a disorder in which the blood clots too readily by

Accepted Answer

A)  deleting a gene for a clotting factor.
B)  blocking transcription of a clotting factor.
C)  increasing susceptibility to a specific viral infection.
D)  increasing the transcription rate of a particular clotting factor gene.

Question 15

The "methylome" is the collection of all the methylated sites in the genome.

Accepted Answer

A) True 
 B)False

Question 16

Which metaphors correctly compare chromatin remodeling and microRNA function?

Accepted Answer

A)  A hammer and a nail
B)  An on/off switch and a dimmer switch
C)  An elevator and a submarine
D)  An activator and a repressor

Question 17

A microRNA is _____ bases long.

Accepted Answer

A)  2 or 4
B)  12 or 13
C)  21 or 22
D)  100 or 110

Question 18

Multiple proteins can be produced from a single gene by

Accepted Answer

A)  intron shuffling.
B)  alternate splicing.
C)  chain switching.
D)  chromatin remodeling. B

Question 19

Noncoding RNAs include all types of RNA molecules except

Accepted Answer

A)  tRNAs.
B)  rRNAs.
C)  HERVs.
D)  mRNAs.

Question 20

"Epigenetic" means

Accepted Answer

A)  "inside the gene."
B)  "inside the protein."
C)  "outside the gene."
D)  "outside the protein."

Exam 11: Gene Expression and Epigenetics

An example of the utility of gene expression profiling in a clinical situation is

Correct AnswerverifiedShow Answer

Histone proteins

Correct AnswerverifiedC

About _____ percent of the human genome actually encodes proteins.

Correct AnswerverifiedShow Answer

The promoter of a gene is the part of a gene where RNA polymerase and transcription factors bind,marking the _____.

Correct AnswerverifiedShow Answer

Modifiers of gene expression include

Correct AnswerverifiedShow Answer

Understanding the signals that activate pancreatic stem cells to differentiate as beta cells could be used to treat

Correct AnswerverifiedShow Answer

The most important chemical group that determines how tightly histones bind DNA is

Correct AnswerverifiedShow Answer

About _____ percent of human genes are alternately spliced.

Correct AnswerverifiedShow Answer

The complexity of microRNA function is that

Correct AnswerverifiedShow Answer

MicroRNAs bind to

Correct AnswerverifiedA

Fetal hemoglobin is hemoglobin that consists of two gamma chains and _____.

Correct AnswerverifiedShow Answer

Fetal hemoglobin carries _____ percent more oxygen than adult hemoglobin.

Correct AnswerverifiedShow Answer

In the adult pancreas,the beta,alpha,gamma,and F cells are

Correct AnswerverifiedShow Answer

A mutation in a promoter causes a disorder in which the blood clots too readily by

Correct AnswerverifiedShow Answer

The "methylome" is the collection of all the methylated sites in the genome.

Correct AnswerverifiedShow Answer

Which metaphors correctly compare chromatin remodeling and microRNA function?

Correct AnswerverifiedShow Answer

A microRNA is _____ bases long.

Correct AnswerverifiedShow Answer

Multiple proteins can be produced from a single gene by

Correct AnswerverifiedB

Noncoding RNAs include all types of RNA molecules except

Correct AnswerverifiedShow Answer

"Epigenetic" means

Correct AnswerverifiedShow Answer

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C

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A

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B

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