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A gene is 13,066 nucleotides long.This is


A) about 1.3 microbases.
B) about 1.3 kilobases.
C) about 1.3 megabases.
D) about 3,011 amino acids.

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Next-generation sequencing reads millions of sequences at once,and so the general approach is also called "massively parallel DNA sequencing."

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In a DNA molecule,the base pairs provide information,and the sugar-phosphate backbone does not,because


A) the base pairs are all the same,but the sugar-phosphate backbone varies.
B) there are eight types of base pairs.
C) the bases form a sequence,and the sugar-phosphate backbone does not.
D) the sugar-phosphate backbone is highly unstable.

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C

Purines and pyrimidines refer to the _____ of the DNA molecules.


A) nitrogenous bases
B) sugar-phosphate backbone
C) hydrogen bonds
D) nucleus
E) histones

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Which of the following statements is true in DNA replication?


A) DNA polymerase unwinds the DNA at replication forks.
B) Primase removes short RNA primers and replaces them with DNA.
C) Ligase breaks the hydrogen bonds between complementary DNA strands.
D) DNA polymerase proofreads DNA,correcting mismatched nucleotides.

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Hydrogen bonds are not as strong as ionic or covalent bonds,but they are able to hold the DNA double helix together because


A) there are so many of them.
B) the hydrogen bonds in DNA differ from hydrogen bonds in other molecules.
C) the hydrogen bonds in DNA also have a very special type of molecular glue.
D) ten of them form between each DNA base pair.

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Meselson and Stahl distinguished between parental and newly-synthesized DNA by using


A) heavy metal.
B) heavy and light forms of nitrogen.
C) nucleic acid dyes.
D) chromosome paints.

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Which of the following were part of the experiments of Hershey and Chase?


A) Mice were injected with type R bacteria and developed pneumoniA.
B) Mice were injected with type S bacteria and developed pneumonia.
C) DNA isolated from type S bacteria killed by heating transformed type R bacteria.
D) E.coli bacteria were infected with virus labeled with radioactive phosphorus.

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In DNA replication,


A) parental DNA shatters into pieces and joins with newly-synthesized pieces to fashion two double helices from one.
B) parental DNA remains intact but guides formation of new double helices.
C) the parental DNA splits and free nucleotides bond to their complements,building two DNA molecules from one.
D) an entirely new double helix is built using information in the sequence of amino acids.

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Erwin Chargaff showed that DNA that has 30% adenine has _____ thymine.


A) 20%
B) 30%
C) 60%
D) 40%

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Okazaki fragments are small pieces of


A) RNA.
B) protein.
C) DNA.
D) enzymes.

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Miescher discovered phosphorus in DNA taken from


A) bacteriA.
B) viruses.
C) soiled bandages.
D) dead mice.

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C

In a molecule of DNA,purine bases form _____ bonds with pyrimidine bases.


A) phosphate
B) hydrogen
C) disulfide
D) covalent

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_____ used models to deduce the double helical shape of DNA.


A) Linus Pauling
B) James Watson and Francis Crick
C) Martha Chase
D) Maclyn McCarty

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When DNA replication halts in a polymerase chain reaction,owing to the incorporation of a tagged base into a growing DNA chain,a(n) _____ results.


A) partial DNA molecule
B) template strand
C) complementary sequence
D) first-generation DNA molecule

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DNA entwined around an octet of proteins is called a(n)


A) nucleotide.
B) karyosome.
C) nucleosome.
D) ribosome.

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DNA in the nucleus winds around proteins called


A) histones.
B) karyosomes.
C) ribosomes.
D) proteasomes.

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Meselson and Stahl's experiments showed that DNA replication is


A) dispersive,conservative,and semi-conservative.
B) dispersive,but not conservative or semi-conservative.
C) semi-conservative,but not dispersive or conservative.
D) quasi-conservative,but not dispersive or semi-conservative.

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Frederick Griffith was a microbiologist who observed that


A) DNA contains nitrogen and phosphorus.
B) proteases disrupt transformation from nonvirulence to virulence.
C) DNA from heat-killed viruses transforms virulent viruses.
D) nonvirulent bacteria become virulent when mixed with heat-killed virulent bacteria.

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D

_____ first noted an acidic substance in the nuclei of cells from pus.


A) Mendel
B) Watson
C) Miescher
D) McCarty

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