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Exam 20: Lipid Metabolism

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Question 21

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Which statement concerning fatty acid synthesis is TRUE? I.The process occurs in the cytosol. II.In eukaryotes, the process occurs on a single large protein. III.The growing acyl chain is carried on an acyl carrier protein instead of coenzyme A. IV.The process requires two NADPH per acetyl group (2 carbons) added.

A) I, II
B) II, III
C) I, II, III, IV
D) III, IV
E) I, III, IV

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Question 22

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Which of the following is NOT an example of a problem sometimes associated with unsaturated fatty acid breakdown?

A) β, $\gamma$ double bond
B) α, β double bond
C) unanticipated isomerization
D) inhibition of hydratase by a double bond
E) All of the above are problems.

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Question 23

Multiple Choice

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Which statement concerning phospholipid synthesis is true?

Which of the following compounds is produced by the multistep cyclization of squalene?

Which of the following would result in a net increase in uptake of LDL by the liver?

An enzyme that is inhibited by the statin group of drugs (e.g.Lipitor) is

Which of the following statements about apolipoproteins (with the possible exception of apoB-100) is TRUE? I.The apolipoproteins are water-soluble and loosely associate with the lipoproteins. II.The apolipoproteins contain helices with hydrophobic and hydrophilic groups on opposite sides of the helical cylinder. III.The apolipoproteins are synthesized in the intestinal tissues. IV.The apolipoproteins appear to float on the surface of phospholipids.

Which of the following vitamins is part of the prosthetic group 5'-deoxyadenosylcobalamin?

Which of the following is required for entry of fatty acids into the oxidation pathway? I.priming via the enzyme acyl CoA synthetase II.conservation of free energy from ATP hydrolysis by use of a thioester linkage III.transport to the cytosol for oxidation via a carnitine carrier protein IV.hydrolysis of carnitine palmitoyl transfer protein

______, a condition in which acetoacetate production exceeds it metabolism and results in a sweet breath odor due to nonenyzmatic ___ of acetoacetate to _____.

Pain and inflammation are triggered by ___ which are synthesized by an enzyme inhibited by ____.

Matching Choose the correct answer from the list. Not all the answers will be used. -Cholesterol and other lipids are transported from tissues to the liver by ________.

PGH₂ is synthesized from ______ and triggers pain and ________.

Which of the following best describes arachidonic acid?

Which of the following diets would most likely promote the formation of ketone bodies?

Matching Choose the correct answer from the list. Not all the answers will be used. -________ is formed from ordered sequence of condensation of isoprene units.

Which of the following accurately ranks lipoproteins from highest to lowest density?

Matching Choose the correct answer from the list. Not all the answers will be used. -Acyl carrier protein (ACP) contains a ________ prosthetic group.

LDL taken up by the liver is

Which of the following is TRUE regarding the enzyme acetyl-CoA carboxylase? I.It catalyzes the first committed step in fatty acid oxidation. II.It requires S-adenosylmethionine. III.It produces malonyl CoA IV.It uses acetyl CoA