Question 1

Pain and inflammation are triggered by ___ which are synthesized by an enzyme inhibited by ____.

Accepted Answer

A)  cardiolipins;aspirin
B)  prostaglandins;aspirin
C)  analgesics;statins
D)  prostaglandins;COX-1
E)  cyclooxygen;NSAIDS

Question 2

Knoop's experiments with fatty acids

Accepted Answer

A)  involved the novel use of chemical labels to elucidate metabolic mechanisms.
B)  demonstrated that fatty acids are broken down by two carbons at a time by oxidation at the ω carbon.
C)  demonstrated a distinct difference in the mechanism of odd chain versus.even chain fatty acid oxidation.
D)  A and B
E)  A,B,and C

Question 3

Which of the following could be produced by the reaction of two or more of phosphatidic acids with two or more glycerol-3-phosphates?
(I) phosphatidylglycerol
(II) cardiolipin
(III) phosphatidylinositol
(IV) gangliosides

Accepted Answer

A)  I,II,III,IV
B)  II,III
C)  I,III
D)  I,II
E)  III only

Question 4

______,a condition in which acetoacetate production exceeds it metabolism and results in a sweet breath odor due to nonenyzmatic ___ of acetoacetate to _____.

Accepted Answer

A)  ketosis;decarboxylation;hydroxylbutryate
B)  ketosis;carboxylation;hydroxylbutryate
C)  ketosis;carboxylation;acetone
D)  glyceroneogenesis;decarboxylation;hydroxylbutryate
E)  glyceroneogenesis;decarboxylation;acetone

Question 5

Matching
Choose the correct answer from the list.Not all the answers will be used.

-The glycerol backbone of triacylglycerols is catabolized to ________ .

Accepted Answer

A)   HDL
B)   propionyl-CoA
C)   LDL
D)   Dihydroxyacetone phosphate
E)   malonyl-CoAF)  ACPG)  chylomicronsH)  phosphopantetheineI)  flavinJ)  albuminK)  ketone bodiesL)  cholesterol

Question 6

Matching
Choose the correct answer from the list.Not all the answers will be used.

-Acyl carrier protein (ACP) contains a ________ prosthetic group.

Accepted Answer

A)   HDL
B)   propionyl-CoA
C)   LDL
D)   Dihydroxyacetone phosphate
E)   malonyl-CoAF)  ACPG)  chylomicronsH)  phosphopantetheineI)  flavinJ)  albuminK)  ketone bodiesL)  cholesterol

Question 7

Which of the following vitamins is part of the prosthetic group 5'-deoxyadenosylcobalamin?

Accepted Answer

A)  B1
B)  B2
C)  B6
D)  B12
E)  none of the above

Question 8

Two phosphatidylglycerol molecules condense to form the molecule ______,and glycerol is eliminated as the side product.

Accepted Answer

A)  phosphatidic acid
B)  cardiolipin
C)  plasmalogen
D)  sphingomyelin
E)  squalene

Question 9

Which of the following is NOT an example of a problem sometimes associated with unsaturated fatty acid breakdown?

Accepted Answer

A)  β, γ\gammaγ  double bond
B)  α,β double bond
C)  unanticipated isomerization
D)  inhibition of hydratase by a double bond
E)  All of the above are problems.

Question 10

Matching
Choose the correct answer from the list.Not all the answers will be used.

-Free fatty acids bind to ________ for circulation in the bloodstream.

Accepted Answer

A)   HDL
B)   propionyl-CoA
C)   LDL
D)   Dihydroxyacetone phosphate
E)   malonyl-CoAF)  ACPG)  chylomicronsH)  phosphopantetheineI)  flavinJ)  albuminK)  ketone bodiesL)  cholesterol

Question 11

An enzyme that is inhibited by the statin group of drugs (e.g.Lipitor®) is

Accepted Answer

A)  phospholipase a2.
B)  hormone sensitive lipase.
C)  HMG CoA reductase.
D)  desaturase.
E)  glycerol kinase.

Question 12

Matching
Choose the correct answer from the list.Not all the answers will be used.

-The molecules acetoacetate,acetone,and d- β\betaβ -hydroxybutyrate are metabolic fuels termed ________.

Accepted Answer

A)   HDL
B)   propionyl-CoA
C)   LDL
D)   Dihydroxyacetone phosphate
E)   malonyl-CoAF)  ACPG)  chylomicronsH)  phosphopantetheineI)  flavinJ)  albuminK)  ketone bodiesL)  cholesterol

Question 13

The mechanism of the condensing enzyme (KS) of fatty acid synthase is best described as

Accepted Answer

A)  base catalysis using a glu residue in the active site
B)  acid catalysis using a glu residue in the active site
C)  base catalysis using a cys residue in the active site
D)  acid catalysis using a cys residue in the active site
E)  covalent catalysis using a cys residue in the active site

Question 14

Matching
Choose the correct answer from the list.Not all the answers will be used.

-Cholesterol and other lipids are transported from tissues to the liver by ________.

Accepted Answer

A)   HDL
B)   propionyl-CoA
C)   LDL
D)   Dihydroxyacetone phosphate
E)   malonyl-CoAF)  ACPG)  chylomicronsH)  phosphopantetheineI)  flavinJ)  albuminK)  ketone bodiesL)  cholesterol

Question 15

Which of the following best describes arachidonic acid?

Accepted Answer

A)  a 20-carbon isoprene-based intermediate of cholesterol synthesis
B)  a 20-carbon fatty acid essential for cholesterol synthesis
C)  a 20-carbon isoprene-based compound used for synthesis of prostaglandins
D)  a 20-carbon fatty acid used for synthesis of prostaglandins
E)  a 2-carbon compound that functions in conjunction with a fatty acid carrier protein for transport of primed fatty acids

Question 16

Which of the following compounds is produced by the multistep cyclization of squalene?

Accepted Answer

A)  lanosterol
B)  geranyl pyrophosphate
C)  fanesyl pyrophosphate
D)  isoprene
E)  isopentyl pyrophosphate

Question 17

What is the net production of ATP from complete catabolism of the following fatty acid to CO2 and H2O?
2 and H2O?   A)

Accepted Answer

A)  
B)  51 - 90 [70]
C)  91 - 120
D)  121 - 150
E)  151 +

Question 18

In which location listed below does the following reaction take place?
HMG-CoA → acetoacetate + Acetyl-CoA

Accepted Answer

A)  cytosol of cardiomyocytes
B)  mitochondria of cardiomyocytes
C)  cytosol of liver cells
D)  mitochondria of liver cells
E)  all of the above

Question 19

PGH2 is synthesized from ______ and triggers pain and ________.

Accepted Answer

A)  cardiolipins;foam cell development
B)  steroids;fever
C)  salicylic acid;foam cell development
D)  NSAIDS;COX-1
E)  arachidonate;inflammation

Question 20

Considering the figure below,what compound would be formed by action of acyl-CoA dehydrogenase?

Accepted Answer

A)   
B)   
C)   
D)   
E)

Exam 20: Lipid Metabolism

An enzyme that is inhibited by the statin group of drugs (e.g.Lipitor®) is

Correct AnswerverifiedShow Answer

PGH2 is synthesized from ______ and triggers pain and ________.

Correct AnswerverifiedShow Answer

______,a condition in which acetoacetate production exceeds it metabolism and results in a sweet breath odor due to nonenyzmatic ___ of acetoacetate to _____.

Correct AnswerverifiedShow Answer

Pain and inflammation are triggered by ___ which are synthesized by an enzyme inhibited by ____.

Correct AnswerverifiedShow Answer

Which of the following vitamins is part of the prosthetic group 5'-deoxyadenosylcobalamin?

Correct AnswerverifiedShow Answer

Knoop's experiments with fatty acids

Correct AnswerverifiedShow Answer

What is the net production of ATP from complete catabolism of the following fatty acid to CO2 and H2O?

Correct AnswerverifiedShow Answer

Matching Choose the correct answer from the list.Not all the answers will be used. -Cholesterol and other lipids are transported from tissues to the liver by ________.

Correct AnswerverifiedShow Answer

Which of the following could be produced by the reaction of two or more of phosphatidic acids with two or more glycerol-3-phosphates? (I) phosphatidylglycerol (II) cardiolipin (III) phosphatidylinositol (IV) gangliosides

Correct AnswerverifiedShow Answer

Which of the following compounds is produced by the multistep cyclization of squalene?

Correct AnswerverifiedShow Answer

Matching Choose the correct answer from the list.Not all the answers will be used. -Acyl carrier protein (ACP) contains a ________ prosthetic group.

Correct AnswerverifiedShow Answer

Two phosphatidylglycerol molecules condense to form the molecule ______,and glycerol is eliminated as the side product.

Correct AnswerverifiedShow Answer

Which of the following is NOT an example of a problem sometimes associated with unsaturated fatty acid breakdown?

Correct AnswerverifiedShow Answer

Matching Choose the correct answer from the list.Not all the answers will be used. -The molecules acetoacetate,acetone,and d- β\betaβ -hydroxybutyrate are metabolic fuels termed ________.

Correct AnswerverifiedShow Answer

Matching Choose the correct answer from the list.Not all the answers will be used. -The glycerol backbone of triacylglycerols is catabolized to ________ .

Correct AnswerverifiedShow Answer

Matching Choose the correct answer from the list.Not all the answers will be used. -Free fatty acids bind to ________ for circulation in the bloodstream.

Correct AnswerverifiedShow Answer

In which location listed below does the following reaction take place? HMG-CoA → acetoacetate + Acetyl-CoA

Correct AnswerverifiedShow Answer

Which of the following best describes arachidonic acid?

Correct AnswerverifiedShow Answer

Considering the figure below,what compound would be formed by action of acyl-CoA dehydrogenase?

Correct AnswerverifiedShow Answer

The mechanism of the condensing enzyme (KS) of fatty acid synthase is best described as

Correct AnswerverifiedShow Answer

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PGH₂ is synthesized from and triggers pain and __.

Correct Answer
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____,a condition in which acetoacetate production exceeds it metabolism and results in a sweet breath odor due to nonenyzmatic _ of acetoacetate to _____.

Correct Answer
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Pain and inflammation are triggered by _ which are synthesized by an enzyme inhibited by __.

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What is the net production of ATP from complete catabolism of the following fatty acid to CO₂ and H₂O?

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Matching Choose the correct answer from the list.Not all the answers will be used. -The molecules acetoacetate,acetone,and d- $\beta$ -hydroxybutyrate are metabolic fuels termed ________.

Correct Answer
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