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Pharmacodynamics describes the physiological processes that act on a drug once it enters the body,or how the body handles the drug.

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Pharmacological effect is achieved by:


A) the portion of free or unbound drug.
B) the portion of protein-bound drug.
C) ionisation.
D) penetrating the blood-brain barrier.

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A drug mechanism that works to neutralise stomach acid is considered to be:


A) an action targeting ion channels.
B) a chemical action.
C) an agonist action.
D) a physical action.

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B

Competitive inhibition slows down the rate of normal chemical reactions because:


A) the normal substrate is malfunctioning.
B) the target enzyme binds temporarily with a look-alike substrate rather than its actual substrate.
C) it takes a long time for the enzyme to develop memory or recognition of the competing substances.
D) it causes enzyme confusion.

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B

Some terms that describe interactions between drugs and receptors include: (Select all that apply)


A) antagonism.
B) agonism.
C) first mechanism
D) first messenger

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In general,a medicine that acts by chemical or physical means can be identified by its dose,which is considerably higher than that required by medicines that act by interacting with a receptor or enzyme system.

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In disrupting the synthesis of folic acid in bacteria,sulfonamides act:


A) as competitive inhibitors.
B) as non-competitive inhibitors.
C) by physical action.
D) by none of the above.

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The extent of binding of a drug to a receptor is termed:


A) potency.
B) specificity.
C) affinity.
D) efficacy.

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Which one of the following statements about pharmacodynamics is true?


A) A partial agonist can be as effective as an antagonist.
B) Ion channels do not have receptors.
C) Second messenger systems always involve G-proteins.
D) The antiasthma agent theophylline acts via a tyrosine kinase-linked receptor.

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A

When a drug acts through non-competitive inhibition of an enzyme,it:


A) can be overcome by giving more of the enzyme substrate.
B) is usually reversible.
C) binds to a distinct site away from the active site.
D) is lethal to the person receiving treatment.

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