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Exam 3: Pharmacodynamics: How Drugs Act

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Question 1

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Richard is participating in a research study involving a new pain medication.But he is not actually receiving the biologically active medication.Research suggests that he:

A) is most likely to fall into the group of participants that sometimes respond to placebo.
B) is likely to always respond to placebo.
C) will not respond at all to the placebo.
D) he is more likely to respond to placebo because he is male.

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Question 2

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The binding site for the endogenous ligand on a receptor is the _____ site.

A) allosteric
B) orthosteric
C) associate
D) facilitator

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Question 3

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Receptors that open and close a channel or pore are known as _____ receptors.

G-protein-coupled receptors are considered to be _____,while ionotropic are _____ receptors.

The _______ can lead to a change in the functional properties of a neuron.

Barbiturates,like benzodiazepines,_____ the effect of GABA on the _____ channel within the GABA receptor.

The dose of drug that produces the effect desired in half of the subjects is called the drug's:

_____ may occur when the effect of two medications oppose each other.

A fast dissociation rate refers to:

The study of what the body does to a drug is _______,and the study of what the drug does to the body is _______.

In the context of polypharmacy,doses may be selected that are ineffective due to side effects,a phenomenon referred to as:

All of the following are second messengers EXCEPT:

All ionotropic receptors _____ ions.

The benzodiazepines such as diazepam bind at _____ site on the receptor as the endogenous neurotransmitter _____ of the neurotransmitter.

Based on the concept of homeostatic control,you might expect drugs that block the action of carrier proteins to _____ the number of postsynaptic receptors for the endogenous neurotransmitter; further,you might expect drugs that facilitate the action of carrier proteins to _____ the number of postsynaptic receptors for the endogenous neurotransmitter.

Ionotropic receptors consist of _____ coils embedded in the membrane with their attachment sites _____ the membrane.

G-protein-coupled receptors consist of a _______ protein chain arranged as _______ transmembrane alpha helices.

The location of the dose-response curve along the horizontal axis reflects:

The therapeutic index refers to the:

All of the following are second messengers EXCEPT: